Role of Long-Range Protein Dynamics in Different Thymidylate Synthase Catalyzed Reactions

Recent studies of Escherichia coli thymidylate synthase (ecTSase) showed that a highly conserved residue, Y209, that is located 8 Å away from the reaction site, plays a key role in the protein’s dynamics. Those crystallographic studies indicated that Y209W mutant is a structurally identical but dyna...

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Detalles Bibliográficos
Autores principales: Abeysinghe, Thelma, Kohen, Amnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425018/
https://www.ncbi.nlm.nih.gov/pubmed/25837629
http://dx.doi.org/10.3390/ijms16047304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425018/
https://www.ncbi.nlm.nih.gov/pubmed/25837629
http://dx.doi.org/10.3390/ijms16047304

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