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Role of Long-Range Protein Dynamics in Different Thymidylate Synthase Catalyzed Reactions
Recent studies of Escherichia coli thymidylate synthase (ecTSase) showed that a highly conserved residue, Y209, that is located 8 Å away from the reaction site, plays a key role in the protein’s dynamics. Those crystallographic studies indicated that Y209W mutant is a structurally identical but dyna...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425018/ https://www.ncbi.nlm.nih.gov/pubmed/25837629 http://dx.doi.org/10.3390/ijms16047304 |