Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs

The deep-sequencing of small RNAs has revealed that different numbers and proportions of miRNA variants called isomiRs are formed from single miRNA genes and that this effect is attributable mainly to imprecise cleavage by Drosha and Dicer. Factors that influence the degree of cleavage precision of...

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Detalles Bibliográficos
Autores principales: Starega-Roslan, Julia, Witkos, Tomasz M., Galka-Marciniak, Paulina, Krzyzosiak, Wlodzimierz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425070/
https://www.ncbi.nlm.nih.gov/pubmed/25867481
http://dx.doi.org/10.3390/ijms16048110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425070/
https://www.ncbi.nlm.nih.gov/pubmed/25867481
http://dx.doi.org/10.3390/ijms16048110

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