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Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies

Wnt-4 (wingless mouse mammary tumor virus integration site-4) protein is involved in many crucial embryonic pathways regulating essential processes. Aberrant Wnt-4 activity causes various anomalies leading to gastric, colon, or breast cancer. Wnt-4 is a conserved protein in structure and sequence. A...

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Detalles Bibliográficos
Autores principales: Hammad, Mirza A, Azam, Syed Sikander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425240/
https://www.ncbi.nlm.nih.gov/pubmed/25995617
http://dx.doi.org/10.2147/DDDT.S79784