Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing

Somatic mutations in KRAS, NRAS, and BRAF genes are related to resistance to anti-EGFR antibodies in colorectal cancer. We have established an extended RAS and BRAF mutation assay using a next-generation sequencer to analyze these mutations. Multiplexed deep sequencing was performed to detect somati...

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Detalles Bibliográficos
Autores principales: Sakai, Kazuko, Tsurutani, Junji, Yamanaka, Takeharu, Yoneshige, Azusa, Ito, Akihiko, Togashi, Yosuke, De Velasco, Marco A., Terashima, Masato, Fujita, Yoshihiko, Tomida, Shuta, Tamura, Takao, Nakagawa, Kazuhiko, Nishio, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425536/
https://www.ncbi.nlm.nih.gov/pubmed/25954997
http://dx.doi.org/10.1371/journal.pone.0121891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425536/
https://www.ncbi.nlm.nih.gov/pubmed/25954997
http://dx.doi.org/10.1371/journal.pone.0121891

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