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Differential DNA mismatch repair underlies mutation rate variation across the human genome
Cancer genome sequencing has revealed considerable variation in somatic mutation rates across the human genome, with mutation rates elevated in heterochromatic late replicating regions and reduced in early replicating euchromatin(1-5). Multiple mechanisms have been suggested to underlie this(2,6-10)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425546/ https://www.ncbi.nlm.nih.gov/pubmed/25707793 http://dx.doi.org/10.1038/nature14173 |