Cargando…

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway

Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs. Luciferase reporter assay screens further identifie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Landais, Igor, Pelton, Chantel, Streblow, Daniel, DeFilippis, Victor, McWeeney, Shannon, Nelson, Jay A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425655/ https://www.ncbi.nlm.nih.gov/pubmed/25955717 http://dx.doi.org/10.1371/journal.ppat.1004881

Ejemplares similares

Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1
por: Albrecht, Valerie, et al.
Publicado: (2008)

Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency
por: Caviness, Katie, et al.
Publicado: (2016)

Tolerogenic dendritic cells and TLR4/IRAK4/NF-κB signaling pathway in allergic rhinitis
por: Kang, Chenglin, et al.
Publicado: (2023)

A Single-Cell Approach to the Elusive Latent Human Cytomegalovirus Transcriptome
por: Goodrum, Felicia, et al.
Publicado: (2018)

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
por: Lin, Su-Chang, et al.
Publicado: (2010)

A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice
por: Conner, James R., et al.
Publicado: (2009)

Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA
por: Traore, Kassim, et al.
Publicado: (2012)

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NF-κB pathway and protecting the intestinal barrier
por: Yan, Bo, et al.
Publicado: (2022)

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling
por: Landers, V. Douglas, et al.
Publicado: (2021)

LPS enhances TLR4 expression and IFN-γ production via the TLR4/IRAK/NF-κB signaling pathway in rat pulmonary arterial smooth muscle cells
por: Wang, Pengyan, et al.
Publicado: (2017)

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome
por: Botto, Sara, et al.
Publicado: (2019)

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling
por: Sandor, Frantisek, et al.
Publicado: (2003)

Expressions of TLR4, MyD88, IRAK4 and NF-ÎB in the oviduct of Chinese brown frog (Rana dybowskii)
por: Zhang, Yue, et al.
Publicado: (2019)

Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112
por: Prod'homme, Virginie, et al.
Publicado: (2010)

The expression of interleukin-32 is activated by human cytomegalovirus infection and down regulated by hcmv-miR-UL112-1
por: Huang, Yujing, et al.
Publicado: (2013)

IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs
por: Guo, L, et al.
Publicado: (2015)

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
por: Pereira, Milton, et al.
Publicado: (2022)

Expression of TLR-2, TLR-4, NOD2 and pNF-κB in a Neonatal Rat Model of Necrotizing Enterocolitis
por: Le Mandat Schultz, Aurelie, et al.
Publicado: (2007)

rhHMGB1 drives osteoblast migration in a TLR2/TLR4- and NF-κB-dependent manner
por: Li, Ming-Jing, et al.
Publicado: (2016)

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway
por: Yoon, Sae-Bom, et al.
Publicado: (2023)

Mmm-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via TLR2, MyD88, and IRAK4
por: Wang, Yang, et al.
Publicado: (2017)

Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis
por: Kim, Geun-Tae, et al.
Publicado: (2009)

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
por: Roshan, Mohsin H. K., et al.
Publicado: (2016)

IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas
por: Küppers, Ralf
Publicado: (2015)

The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes
por: Ryu, Sunhyo, et al.
Publicado: (2015)

Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV)
por: Manska, Salome, et al.
Publicado: (2021)

The Human Cytomegalovirus UL76 Gene Regulates the Level of Expression of the UL77 Gene
por: Isomura, Hiroki, et al.
Publicado: (2010)

The Role of the Human Cytomegalovirus UL133-UL138 Gene Locus in Latency and Reactivation
por: Mlera, Luwanika, et al.
Publicado: (2020)

Characterization of the transcripts of human cytomegalovirus UL144
por: He, Rong, et al.
Publicado: (2011)

Rhinovirus Attenuates Non-typeable Hemophilus influenzae-stimulated IL-8 Responses via TLR2-dependent Degradation of IRAK-1
por: Unger, Benjamin L., et al.
Publicado: (2012)

Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
por: Campbell, Grant R., et al.
Publicado: (2022)

Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-κB and Protects Rat Brains against Focal Ischemia
por: Fan, Hongguang, et al.
Publicado: (2009)

Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB after Cerebral Ischemia in Rats
por: Ma, Yuewen, et al.
Publicado: (2013)

Differences in the Expression of TLR-2, NOD2, and NF-κB in Placenta Between Twins
por: Szylberg, Łukasz, et al.
Publicado: (2018)

The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein
por: Shannon-Lowe, Claire D, et al.
Publicado: (2010)

Polymorphisms and features of cytomegalovirus UL144 and UL146 in congenitally infected neonates with hepatic involvement
por: Guo, Gangqiang, et al.
Publicado: (2017)

TLR2 and TLR4 in Ischemia Reperfusion Injury
por: Arslan, F., et al.
Publicado: (2010)

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
por: Maeda, Shin
Publicado: (2010)

Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway
por: Zhang, Qingwen, et al.
Publicado: (2020)

Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ
por: Hancock, Meaghan H., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_752hsblj4sket1eukn3mu8600n