Cargando…

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells

BACKGROUND: Mycobacterium tuberculosis continues to kill more people than any other bacterium. Although its archetypal host cell is the macrophage, it also enters, and survives within, dendritic cells (DCs). By modulating the behaviour of the DC, M. tuberculosis is able to manipulate the host’s immu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendum, Tom A, Wu, Huihai, Kierzek, Andrzej M, Stewart, Graham R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425887/ https://www.ncbi.nlm.nih.gov/pubmed/25956932 http://dx.doi.org/10.1186/s12864-015-1569-2

Ejemplares similares

Mycobacterium bovis uses the ESX-1 Type VII secretion system to escape predation by the soil-dwelling amoeba Dictyostelium discoideum
por: Butler, Rachel E, et al.
Publicado: (2020)

Systems-Based Approaches to Probing Metabolic Variation within the Mycobacterium tuberculosis Complex
por: Lofthouse, Emma K., et al.
Publicado: (2013)

A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks
por: López-Agudelo, Víctor A., et al.
Publicado: (2020)

Mycobacterium leprae genomes from a British medieval leprosy hospital: towards understanding an ancient epidemic
por: Mendum, Tom A, et al.
Publicado: (2014)

Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages
por: Borah, Khushboo, et al.
Publicado: (2019)

The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis
por: Gijsbers, Abril, et al.
Publicado: (2022)

GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism
por: Beste, Dany JV, et al.
Publicado: (2007)

Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera
por: Mendum, Tom A, et al.
Publicado: (2011)

Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion
por: Izquierdo Lafuente, B., et al.
Publicado: (2021)

Computational Analysis of the ESX-1 Region of Mycobacterium tuberculosis: Insights into the Mechanism of Type VII Secretion System
por: Das, Chandrani, et al.
Publicado: (2011)

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
por: Mehra, Alka, et al.
Publicado: (2013)

Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response
por: Mittal, Ekansh, et al.
Publicado: (2018)

A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
por: Zhang, Lei, et al.
Publicado: (2022)

Mycobacterium tuberculosis and lipids: Insights into molecular mechanisms from persistence to virulence
por: Ghazaei, Ciamak
Publicado: (2018)

Virulence-Associated Secretion in Mycobacterium abscessus
por: Bar-Oz, Michal, et al.
Publicado: (2022)

Pathogenicity and virulence of Mycobacterium tuberculosis
por: Rahlwes, Kathryn C., et al.
Publicado: (2023)

A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence
por: Spencer, Brady L., et al.
Publicado: (2021)

Susceptibility of Mycobacterium tuberculosis-infected host cells to phospho-MLKL driven necroptosis is dependent on cell type and presence of TNFα
por: Butler, Rachel E., et al.
Publicado: (2017)

Virulence factors of the Mycobacterium tuberculosis complex
por: Forrellad, Marina A., et al.
Publicado: (2013)

Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis
por: Augenstreich, Jacques, et al.
Publicado: (2020)

Biosynthesis and Virulent Behavior of Lipids Produced by Mycobacterium tuberculosis: LAM and Cord Factor: An Overview
por: Rajni,, et al.
Publicado: (2010)

283. Screening the PE/PPE secreted effectors of Mycobacterium tuberculosis to uncover novel virulence-promoting genes
por: Koleske, Benjamin, et al.
Publicado: (2023)

Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells
por: Ramos-Martinez, Ana Gabriela, et al.
Publicado: (2019)

Secret Remedies and Branded Products—VII
Publicado: (1908)

Toxin secretion and trafficking by Mycobacterium tuberculosis
por: Pajuelo, David, et al.
Publicado: (2021)

The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence
por: Butler, Rachel E., et al.
Publicado: (2012)

The role of dendritic cells in Mycobacterium tuberculosis infection
por: Mihret, Adane
Publicado: (2012)

Systematic Genetic Nomenclature for Type VII Secretion Systems
por: Bitter, Wilbert, et al.
Publicado: (2009)

The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis
por: Basu, Piyali, et al.
Publicado: (2018)

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production
por: Leoncikas, Vytautas, et al.
Publicado: (2016)

Crosstalk between the ancestral type VII secretion system ESX-4 and other T7SS in Mycobacterium marinum
por: Wang, Yuchen, et al.
Publicado: (2021)

Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis
por: Borah, Khushboo, et al.
Publicado: (2021)

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein
por: Blasco, Benjamin, et al.
Publicado: (2012)

Editorial: Cellular and Molecular Mechanisms of Mycobacterium tuberculosis Virulence
por: Sun, Jianjun, et al.
Publicado: (2019)

Phosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence
por: Malakar, Basanti, et al.
Publicado: (2023)

Mycobacterium tuberculosis virulence inhibitors discovered by Mycobacterium marinum high-throughput screening
por: Tükenmez, Hasan, et al.
Publicado: (2019)

Dominant Mycobacterium tuberculosis Lineages in Elderly Patients Born in Norway
por: Kinander, Wibeke, et al.
Publicado: (2009)

FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis
por: Mondino, Sonia, et al.
Publicado: (2020)

Mycobacterium tuberculosis Lineage Influences Innate Immune Response and Virulence and Is Associated with Distinct Cell Envelope Lipid Profiles
por: Krishnan, Nitya, et al.
Publicado: (2011)

972. A Mycobacterium tuberculosis Secreted Lipid Triggers Cough Through a Neuronal Cough Receptor
por: Cruz, Paxton, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pb87rnn5pnqdslqf6kp2kku9h9