Cargando…
Protective role of female gender in programmed accelerated renal aging in the rat
The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally pr...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425955/ https://www.ncbi.nlm.nih.gov/pubmed/25902787 http://dx.doi.org/10.14814/phy2.12342 |
_version_ | 1782370551131537408 |
---|---|
author | Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A Langley-Evans, Simon McMullen, Sarah |
author_facet | Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A Langley-Evans, Simon McMullen, Sarah |
author_sort | Pijacka, Wioletta |
collection | PubMed |
description | The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally programmed accelerated renal aging in the rat, superimposed by ovariectomy to assess interactions between ovarian hormones and the aging process. Under our experimental conditions, we found that kidney function worsens with age, that is GFR reduces over 18 month analyzed time-course and this was worsened by fetal exposure to maternal low-protein diet and absence of estrogen. Reduction in GFR was followed by increases in albuminuria, proteinuria, inflammatory markers, and tissue carbonyls, all suggesting inflammatory response and oxidative stress. This was associated with changes in AGTR2 expression which was greater at 18 months of age compared to earlier time points, but in MLP offspring only. Our studies show an influence of ovarian hormones on programmed accelerated renal aging and the AGTR2 across the lifespan. The main findings are that ovariectomy is a risk factor for increased aging-related renal injury and that this and oxidative damage might be related to changes in AGTR2 expression. |
format | Online Article Text |
id | pubmed-4425955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44259552015-05-14 Protective role of female gender in programmed accelerated renal aging in the rat Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A Langley-Evans, Simon McMullen, Sarah Physiol Rep Original Research The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally programmed accelerated renal aging in the rat, superimposed by ovariectomy to assess interactions between ovarian hormones and the aging process. Under our experimental conditions, we found that kidney function worsens with age, that is GFR reduces over 18 month analyzed time-course and this was worsened by fetal exposure to maternal low-protein diet and absence of estrogen. Reduction in GFR was followed by increases in albuminuria, proteinuria, inflammatory markers, and tissue carbonyls, all suggesting inflammatory response and oxidative stress. This was associated with changes in AGTR2 expression which was greater at 18 months of age compared to earlier time points, but in MLP offspring only. Our studies show an influence of ovarian hormones on programmed accelerated renal aging and the AGTR2 across the lifespan. The main findings are that ovariectomy is a risk factor for increased aging-related renal injury and that this and oxidative damage might be related to changes in AGTR2 expression. BlackWell Publishing Ltd 2015-04-22 /pmc/articles/PMC4425955/ /pubmed/25902787 http://dx.doi.org/10.14814/phy2.12342 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Pijacka, Wioletta Clifford, Bethan Tilburgs, Chantal Joles, Jaap A Langley-Evans, Simon McMullen, Sarah Protective role of female gender in programmed accelerated renal aging in the rat |
title | Protective role of female gender in programmed accelerated renal aging in the rat |
title_full | Protective role of female gender in programmed accelerated renal aging in the rat |
title_fullStr | Protective role of female gender in programmed accelerated renal aging in the rat |
title_full_unstemmed | Protective role of female gender in programmed accelerated renal aging in the rat |
title_short | Protective role of female gender in programmed accelerated renal aging in the rat |
title_sort | protective role of female gender in programmed accelerated renal aging in the rat |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425955/ https://www.ncbi.nlm.nih.gov/pubmed/25902787 http://dx.doi.org/10.14814/phy2.12342 |
work_keys_str_mv | AT pijackawioletta protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat AT cliffordbethan protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat AT tilburgschantal protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat AT jolesjaapa protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat AT langleyevanssimon protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat AT mcmullensarah protectiveroleoffemalegenderinprogrammedacceleratedrenalagingintherat |