Pathway-Based Factor Analysis of Gene Expression Data Produces Highly Heritable Phenotypes That Associate with Age

Statistical factor analysis methods have previously been used to remove noise components from high-dimensional data prior to genetic association mapping and, in a guided fashion, to summarize biologically relevant sources of variation. Here, we show how the derived factors summarizing pathway expres...

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Detalles Bibliográficos
Autores principales: Anand Brown, Andrew, Ding, Zhihao, Viñuela, Ana, Glass, Dan, Parts, Leopold, Spector, Tim, Winn, John, Durbin, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426370/
https://www.ncbi.nlm.nih.gov/pubmed/25758824
http://dx.doi.org/10.1534/g3.114.011411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426370/
https://www.ncbi.nlm.nih.gov/pubmed/25758824
http://dx.doi.org/10.1534/g3.114.011411

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