Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like small molecule, renders cells insensitive to eIF2α pho...

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Detalles Bibliográficos
Autores principales: Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426669/
https://www.ncbi.nlm.nih.gov/pubmed/25875391
http://dx.doi.org/10.7554/eLife.07314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426669/
https://www.ncbi.nlm.nih.gov/pubmed/25875391
http://dx.doi.org/10.7554/eLife.07314

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