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Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations
Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no re...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426692/ https://www.ncbi.nlm.nih.gov/pubmed/25960144 http://dx.doi.org/10.1038/srep10182 |