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The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects

Excitotoxicity is a major contributor to cell death during the acute phase of ischemic stroke but aggressive pharmacological targeting of excitotoxicity has failed clinically. Here we investigated whether pretreatment with low doses of memantine, within the range currently used and well tolerated fo...

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Detalles Bibliográficos
Autores principales: Trotman, Melissa, Vermehren, Philipp, Gibson, Claire L, Fern, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426739/
https://www.ncbi.nlm.nih.gov/pubmed/25407270
http://dx.doi.org/10.1038/jcbfm.2014.188