Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

The energy required to fuse synaptic vesicles with the plasma membrane (‘activation energy’) is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class of modulations exists, which utilize linear modulation of the energy barrier for fusion to achieve s...

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Detalles Bibliográficos
Autores principales: Schotten, Sebastiaan, Meijer, Marieke, Walter, Alexander Matthias, Huson, Vincent, Mamer, Lauren, Kalogreades, Lawrence, ter Veer, Mirelle, Ruiter, Marvin, Brose, Nils, Rosenmund, Christian, Sørensen, Jakob Balslev, Verhage, Matthijs, Cornelisse, Lennart Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426983/
https://www.ncbi.nlm.nih.gov/pubmed/25871846
http://dx.doi.org/10.7554/eLife.05531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426983/
https://www.ncbi.nlm.nih.gov/pubmed/25871846
http://dx.doi.org/10.7554/eLife.05531

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