Effective small interfering RNA delivery in vitro via a new stearylated cationic peptide

A crucial bottleneck in RNA interference-based gene therapy is the lack of safe and efficient delivery systems. Here, a novel small interfering RNA (siRNA) delivery peptide, STR-HK, was constructed by conjugating a stearyl end to the N-terminus of the peptide sequence HHHPKPKRKV, where PKPKRKV is an...

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Detalles Bibliográficos
Autores principales: Chen, Baoling, Pan, Ran, Askhatova, Diana, Chen, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427069/
https://www.ncbi.nlm.nih.gov/pubmed/25999710
http://dx.doi.org/10.2147/IJN.S79306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427069/
https://www.ncbi.nlm.nih.gov/pubmed/25999710
http://dx.doi.org/10.2147/IJN.S79306

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