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Effective small interfering RNA delivery in vitro via a new stearylated cationic peptide

A crucial bottleneck in RNA interference-based gene therapy is the lack of safe and efficient delivery systems. Here, a novel small interfering RNA (siRNA) delivery peptide, STR-HK, was constructed by conjugating a stearyl end to the N-terminus of the peptide sequence HHHPKPKRKV, where PKPKRKV is an...

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Detalles Bibliográficos
Autores principales:	Chen, Baoling, Pan, Ran, Askhatova, Diana, Chen, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427069/ https://www.ncbi.nlm.nih.gov/pubmed/25999710 http://dx.doi.org/10.2147/IJN.S79306

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