eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells

OBJECTIVE: We investigated whether glutamate, NMDA receptors, and eukaryote elongation factor-2 kinase (eEF-2K)/eEF-2 regulate P-glycoprotein expression, and the effects of the eEF-2K inhibitor NH125 on the expression of P-glycoprotein in rat brain microvessel endothelial cells (RBMECs). METHODS: Co...

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Detalles Bibliográficos
Autores principales: Tang, Xing Hua, Wu, Xun Yi, Xu, Lan, Fang, You Xin, Wang, Ping, Zhu, Guo Xing, Hong, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427111/
https://www.ncbi.nlm.nih.gov/pubmed/25962137
http://dx.doi.org/10.1371/journal.pone.0125389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427111/
https://www.ncbi.nlm.nih.gov/pubmed/25962137
http://dx.doi.org/10.1371/journal.pone.0125389

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