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eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells

OBJECTIVE: We investigated whether glutamate, NMDA receptors, and eukaryote elongation factor-2 kinase (eEF-2K)/eEF-2 regulate P-glycoprotein expression, and the effects of the eEF-2K inhibitor NH125 on the expression of P-glycoprotein in rat brain microvessel endothelial cells (RBMECs). METHODS: Co...

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Detalles Bibliográficos
Autores principales:	Tang, Xing Hua, Wu, Xun Yi, Xu, Lan, Fang, You Xin, Wang, Ping, Zhu, Guo Xing, Hong, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427111/ https://www.ncbi.nlm.nih.gov/pubmed/25962137 http://dx.doi.org/10.1371/journal.pone.0125389

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