Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment of Cryptosporidium infections. Here, the structure of C. parvum IMPDH (CpIMPDH) in complex with inosine 5′-monophosphate (IMP) and P131, an inhibitor with in vivo anticryptosporidial activity, is reported. P131 co...

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Detalles Bibliográficos
Autores principales: Kim, Youngchang, Makowska-Grzyska, Magdalena, Gorla, Suresh Kumar, Gollapalli, Deviprasad R., Cuny, Gregory D., Joachimiak, Andrzej, Hedstrom, Lizbeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Molecular Parasitology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427161/
https://www.ncbi.nlm.nih.gov/pubmed/25945705
http://dx.doi.org/10.1107/S2053230X15000187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427161/
https://www.ncbi.nlm.nih.gov/pubmed/25945705
http://dx.doi.org/10.1107/S2053230X15000187

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