Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein–protein interactions

The most severe form of malaria is caused by the obligate parasite Plasmodium falciparum. Orotate phosphoribosyltransferase (OPRTase) is the fifth enzyme in the de novo pyrimidine-synthesis pathway in the parasite, which lacks salvage pathways. Among all of the malaria de novo pyrimidine-biosynthesi...

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Detalles Bibliográficos
Autores principales: Kumar, Shiva, Krishnamoorthy, Kalyanaraman, Mudeppa, Devaraja G., Rathod, Pradipsinh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Molecular Parasitology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427171/
https://www.ncbi.nlm.nih.gov/pubmed/25945715
http://dx.doi.org/10.1107/S2053230X1500549X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427171/
https://www.ncbi.nlm.nih.gov/pubmed/25945715
http://dx.doi.org/10.1107/S2053230X1500549X

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