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Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein–protein interactions
The most severe form of malaria is caused by the obligate parasite Plasmodium falciparum. Orotate phosphoribosyltransferase (OPRTase) is the fifth enzyme in the de novo pyrimidine-synthesis pathway in the parasite, which lacks salvage pathways. Among all of the malaria de novo pyrimidine-biosynthesi...
Autores principales: | Kumar, Shiva, Krishnamoorthy, Kalyanaraman, Mudeppa, Devaraja G., Rathod, Pradipsinh K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427171/ https://www.ncbi.nlm.nih.gov/pubmed/25945715 http://dx.doi.org/10.1107/S2053230X1500549X |
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