Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation

The M2 isoform of pyruvate kinase M2 (PKM2) has been shown to be up-regulated in human skin cancers. To test whether PKM2 may be a target for chemoprevention, shikonin, a natural product from the root of Lithospermum erythrorhizon and a specific inhibitor of PKM2, was used in a chemically-induced mo...

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Detalles Bibliográficos
Autores principales: Li, Wenjuan, Zhang, Chunjing, Ren, Amy, Li, Teena, Jin, Rong, Li, Guohong, Gu, Xin, Shi, Runhua, Zhao, Yunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427333/
https://www.ncbi.nlm.nih.gov/pubmed/25961580
http://dx.doi.org/10.1371/journal.pone.0126459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427333/
https://www.ncbi.nlm.nih.gov/pubmed/25961580
http://dx.doi.org/10.1371/journal.pone.0126459

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