IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

Intravital visualization of thrombopoiesis revealed that formation of proplatelets, which are cytoplasmic protrusions in bone marrow megakaryocytes (MKs), is dominant in the steady state. However, it was unclear whether this is the only path to platelet biogenesis. We have identified an alternative...

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Detalles Bibliográficos
Autores principales: Nishimura, Satoshi, Nagasaki, Mika, Kunishima, Shinji, Sawaguchi, Akira, Sakata, Asuka, Sakaguchi, Hiroyasu, Ohmori, Tsukasa, Manabe, Ichiro, Italiano, Joseph E., Ryu, Tomiko, Takayama, Naoya, Komuro, Issei, Kadowaki, Takashi, Eto, Koji, Nagai, Ryozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427781/
https://www.ncbi.nlm.nih.gov/pubmed/25963822
http://dx.doi.org/10.1083/jcb.201410052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427781/
https://www.ncbi.nlm.nih.gov/pubmed/25963822
http://dx.doi.org/10.1083/jcb.201410052

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