Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis

Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play roles in cell cycle progression and primary cilia function. Here, we show that Nek5, similar to Nek2, localizes to the proximal ends of centrioles. Depletion of Nek5 or overexpression of kinase-inact...

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Detalles Bibliográficos
Autores principales: Prosser, Suzanna L., Sahota, Navdeep K., Pelletier, Laurence, Morrison, Ciaran G., Fry, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427792/
https://www.ncbi.nlm.nih.gov/pubmed/25963817
http://dx.doi.org/10.1083/jcb.201412099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427792/
https://www.ncbi.nlm.nih.gov/pubmed/25963817
http://dx.doi.org/10.1083/jcb.201412099

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