Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo

The myelination of axons by oligodendrocytes profoundly affects central nervous system function, but how this is regulated by neuronal activity in vivo is not known. Here we find that blocking synaptic vesicle release impairs CNS myelination by reducing the number of myelin sheaths made by individua...

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Autores principales: Mensch, Sigrid, Baraban, Marion, Almeida, Rafael, Czopka, Tim, Ausborn, Jessica, El Manira, Abdel, Lyons, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427868/
https://www.ncbi.nlm.nih.gov/pubmed/25849985
http://dx.doi.org/10.1038/nn.3991
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author Mensch, Sigrid
Baraban, Marion
Almeida, Rafael
Czopka, Tim
Ausborn, Jessica
El Manira, Abdel
Lyons, David A
author_facet Mensch, Sigrid
Baraban, Marion
Almeida, Rafael
Czopka, Tim
Ausborn, Jessica
El Manira, Abdel
Lyons, David A
author_sort Mensch, Sigrid
collection PubMed
description The myelination of axons by oligodendrocytes profoundly affects central nervous system function, but how this is regulated by neuronal activity in vivo is not known. Here we find that blocking synaptic vesicle release impairs CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also find that stimulating neuronal activity increases myelin sheath formation by individual oligodendrocytes. These data show that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
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spelling pubmed-44278682015-11-01 Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo Mensch, Sigrid Baraban, Marion Almeida, Rafael Czopka, Tim Ausborn, Jessica El Manira, Abdel Lyons, David A Nat Neurosci Article The myelination of axons by oligodendrocytes profoundly affects central nervous system function, but how this is regulated by neuronal activity in vivo is not known. Here we find that blocking synaptic vesicle release impairs CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also find that stimulating neuronal activity increases myelin sheath formation by individual oligodendrocytes. These data show that neuronal activity regulates the myelinating capacity of single oligodendrocytes. 2015-04-06 2015-05 /pmc/articles/PMC4427868/ /pubmed/25849985 http://dx.doi.org/10.1038/nn.3991 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mensch, Sigrid
Baraban, Marion
Almeida, Rafael
Czopka, Tim
Ausborn, Jessica
El Manira, Abdel
Lyons, David A
Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title_full Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title_fullStr Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title_full_unstemmed Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title_short Synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
title_sort synaptic vesicle release regulates the number of myelin sheaths made by individual oligodendrocytes in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427868/
https://www.ncbi.nlm.nih.gov/pubmed/25849985
http://dx.doi.org/10.1038/nn.3991
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