Cargando…

Visualizing KcsA Conformational Changes upon Ion Binding by Infrared Spectroscopy and Atomistic Modeling

[Image: see text] The effect of ion binding in the selectivity filter of the potassium channel KcsA is investigated by combining amide I Fourier-transform infrared spectroscopy with structure-based spectral modeling. Experimental difference IR spectra between K(+)-bound KcsA and Na(+)-bound KcsA are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stevenson, Paul, Götz, Christoph, Baiz, Carlos R., Akerboom, Jasper, Tokmakoff, Andrei, Vaziri, Alipasha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428008/ https://www.ncbi.nlm.nih.gov/pubmed/25861001 http://dx.doi.org/10.1021/acs.jpcb.5b02223

Ejemplares similares

Conformational Dynamics at the Inner Gate of KcsA during Activation
por: Hulse, Raymond E., et al.
Publicado: (2014)

Thermodynamics of ion selectivity in the KcsA K(+) channel
por: Dixit, Purushottam D., et al.
Publicado: (2011)

pH-Dependent Conformational Changes of KcsA Tetramer and Monomer Probed by Raman Spectroscopy
por: Kniggendorf, Ann-Kathrin, et al.
Publicado: (2019)

Inactivation in the potassium channel KcsA()
por: Xu, Yunyao, et al.
Publicado: (2019)

Barium blockade of the KcsA channel in open and closed conformation datasets
por: Rohaim, Ahmed, et al.
Publicado: (2020)

Non-Equilibrium Dynamics Contribute to Ion Selectivity in the KcsA Channel
por: Ngo, Van, et al.
Publicado: (2014)

Regulation of Ion Permeation of the KcsA Channel by Applied Midinfrared Field
por: Wang, Yize, et al.
Publicado: (2022)

Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles
por: Kim, Dorothy M., et al.
Publicado: (2016)

Inactivation of the KcsA potassium channel explored with heterotetramers
por: Rotem, Dvir, et al.
Publicado: (2010)

Probing Ion Configurations in the KcsA Selectivity Filter with Single-Isotope Labels and 2D IR Spectroscopy
por: Ryan, Matthew J., et al.
Publicado: (2023)

Dynamic water patterns change the stability of the collapsed filter conformation of the KcsA K(+) channel
por: Wu, Di
Publicado: (2017)

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies
por: Renart, M. Lourdes, et al.
Publicado: (2019)

Biomimetic KcsA channels with ultra-selective K(+) transport for monovalent ion sieving
por: Xin, Weiwen, et al.
Publicado: (2022)

Mechanism of activation at the selectivity filter of the KcsA K(+) channel
por: Heer, Florian T, et al.
Publicado: (2017)

The influence of membrane bilayer thickness on KcsA channel activity
por: Callahan, Karen M., et al.
Publicado: (2019)

Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two Gates for Ion Conduction
por: Blunck, Rikard, et al.
Publicado: (2006)

Anionic Phospholipids Shift the Conformational Equilibrium of the Selectivity Filter in the KcsA Channel to the Conductive Conformation: Predicted Consequences on Inactivation
por: Renart, María Lourdes, et al.
Publicado: (2023)

Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels
por: Noskov, Sergei Yu., et al.
Publicado: (2007)

A Quantitative Description of KcsA Gating I: Macroscopic Currents
por: Chakrapani, Sudha, et al.
Publicado: (2007)

Multiple Binding Sites for Fatty Acids on the Potassium Channel KcsA
por: Bolivar, Juan H., et al.
Publicado: (2012)

Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels
por: Noskov, Sergei Yu., et al.
Publicado: (2011)

Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA
por: Kiya, Takunari, et al.
Publicado: (2022)

Molecular Architecture of Full-Length KcsA : Role of Cytoplasmic Domains in Ion Permeation and Activation Gating
por: Cortes, D. Marien, et al.
Publicado: (2001)

Specific interactions between alkali metal cations and the KcsA channel studied using ATR-FTIR spectroscopy
por: Furutani, Yuji, et al.
Publicado: (2015)

A Quantitative Description of KcsA Gating II: Single-Channel Currents
por: Chakrapani, Sudha, et al.
Publicado: (2007)

Potassium-selective block of barium permeation through single KcsA channels
por: Piasta, Kene N., et al.
Publicado: (2011)

Characterizing the Fatty Acid Binding Site in the Cavity of Potassium Channel KcsA
por: Smithers, Natalie, et al.
Publicado: (2012)

Probing the Energy Landscape of Activation Gating of the Bacterial Potassium Channel KcsA
por: Linder, Tobias, et al.
Publicado: (2013)

Molecular interactions involved in proton-dependent gating in KcsA potassium channels
por: Posson, David J., et al.
Publicado: (2013)

Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel
por: Cosseddu, Salvatore M., et al.
Publicado: (2021)

Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel
por: Pérez-Conesa, Sergio, et al.
Publicado: (2021)

The Role of Phosphatidic Acid and Cardiolipin in Stability of the Tetrameric Assembly of Potassium Channel KcsA
por: Raja, Mobeen
Publicado: (2010)

The Role of Extramembranous Cytoplasmic Termini in Assembly and Stability of the Tetrameric K(+)-Channel KcsA
por: Raja, Mobeen
Publicado: (2010)

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study
por: Giudici, Ana Marcela, et al.
Publicado: (2019)

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA
por: Delemotte, Lucie
Publicado: (2018)

Probing the Structural Dynamics of the Activation Gate of KcsA Using Homo-FRET Measurements
por: Díaz-García, Clara, et al.
Publicado: (2021)

A Multi-Scale Approach to Model K(+) Permeation Through the KcsA Channel
por: Horng, T. L., et al.
Publicado: (2022)

Functional Role and Affinity of Inorganic Cations in Stabilizing the Tetrameric Structure of the KcsA K(+) Channel
por: Krishnan, Manoj N., et al.
Publicado: (2005)

Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel
por: Li, Jing, et al.
Publicado: (2018)

Modulation of Function, Structure and Clustering of K(+) Channels by Lipids: Lessons Learnt from KcsA
por: Renart, María Lourdes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5njp7hj1jgp8pt7lrocv1tl013