USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Mitochondria play a pivotal role in the orchestration of cell death pathways. Here, we show that the control of ubiquitin dynamics at mitochondria contributes to the regulation of apoptotic cell death. The unique mitochondrial deubiquitylase, USP30, opposes Parkin-dependent ubiquitylation of TOM20,...

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Detalles Bibliográficos
Autores principales: Liang, Jin-Rui, Martinez, Aitor, Lane, Jon D, Mayor, Ugo, Clague, Michael J, Urbé, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428036/
https://www.ncbi.nlm.nih.gov/pubmed/25739811
http://dx.doi.org/10.15252/embr.201439820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428036/
https://www.ncbi.nlm.nih.gov/pubmed/25739811
http://dx.doi.org/10.15252/embr.201439820

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