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Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain

BACKGROUND: Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the Aβ deposition in leptomeninge. The cellular origin of angiopathic Aβ and the p...

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Detalles Bibliográficos
Autores principales: Xue, Zhi-Qin, He, Zheng-Wen, Yu, Jian-Jun, Cai, Yan, Qiu, Wen-Ying, Pan, Aihua, Gai, Wei-Ping, Cai, Huaibin, Luo, Xue-Gang, Ma, Chao, Yan, Xiao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428107/
https://www.ncbi.nlm.nih.gov/pubmed/25934480
http://dx.doi.org/10.1186/s12883-015-0327-z