The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

Effective mucosal adjuvants enhance the magnitude and quality of the vaccine response. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant. However, its in vivo mechanisms are unclear. Here, we showed, in mice, that CDG elicits stronger Ab and T(H) responses than the mammalian 2′3′-cyclic GM...

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Detalles Bibliográficos
Autores principales: Blaauboer, Steven M, Mansouri, Samira, Tucker, Heidi R, Wang, Hatti L, Gabrielle, Vincent D, Jin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428110/
https://www.ncbi.nlm.nih.gov/pubmed/25898005
http://dx.doi.org/10.7554/eLife.06670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428110/
https://www.ncbi.nlm.nih.gov/pubmed/25898005
http://dx.doi.org/10.7554/eLife.06670

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