Cargando…

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

Effective mucosal adjuvants enhance the magnitude and quality of the vaccine response. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant. However, its in vivo mechanisms are unclear. Here, we showed, in mice, that CDG elicits stronger Ab and T(H) responses than the mammalian 2′3′-cyclic GM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blaauboer, Steven M, Mansouri, Samira, Tucker, Heidi R, Wang, Hatti L, Gabrielle, Vincent D, Jin, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428110/ https://www.ncbi.nlm.nih.gov/pubmed/25898005 http://dx.doi.org/10.7554/eLife.06670

Ejemplares similares

Immature lung TNFR2(−) conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
por: Mansouri, Samira, et al.
Publicado: (2018)

Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
por: Škrnjug, Ivana, et al.
Publicado: (2014)

Correction: Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
Publicado: (2015)

THE UPTAKE OF FLUORESCENT ALBUMIN BY PINOCYTOSIS IN Amoeba proteus
por: Chapman-Andresen, Cicily, et al.
Publicado: (1960)

New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice
por: Gogoi, Himanshu, et al.
Publicado: (2020)

Nitric oxide regulated cyclic di-GMP signaling
por: Boon, Elizabeth M, et al.
Publicado: (2013)

Cyclic di-GMP signalling and the regulation of bacterial virulence
por: Ryan, Robert P.
Publicado: (2013)

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria
por: Valentini, Martina, et al.
Publicado: (2016)

A cyclic-di-GMP receptor required for bacterial exopolysaccharide production
por: Lee, Vincent T, et al.
Publicado: (2007)

Sucrose uptake by pinocytosis in Amoeba proteus and the influence of external calcium
Publicado: (1979)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
por: Onyedibe, Kenneth I., et al.
Publicado: (2021)

Mechanism of activation of bacterial cellulose synthase by cyclic-di-GMP
por: Morgan, Jacob L. W., et al.
Publicado: (2014)

Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide
por: Zhang, Hai-Nan, et al.
Publicado: (2017)

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems
por: Roelofs, Kevin G., et al.
Publicado: (2015)

Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches
por: Keller, Heiko, et al.
Publicado: (2018)

Visualization of c-di-GMP in multicellular Dictyostelium stages
por: Ide, Hayato, et al.
Publicado: (2023)

AN ELECTRON MICROSCOPIC STUDY OF PINOCYTOSIS IN AMEBA : II. The Cytoplasmic Uptake Phase
por: Brandt, Philip W., et al.
Publicado: (1962)

From Pinocytosis to Methuosis—Fluid Consumption as a Risk Factor for Cell Death
por: Ritter, Markus, et al.
Publicado: (2021)

The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages
por: Škrnjug, Ivana, et al.
Publicado: (2014)

A study of Chitosan and c‐di‐GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine
por: Svindland, Signe C., et al.
Publicado: (2012)

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks
por: He, Ming, et al.
Publicado: (2011)

STING is a direct innate immune sensor of cyclic-di-GMP
por: Burdette, Dara L., et al.
Publicado: (2011)

Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia
por: Richter, Anja M., et al.
Publicado: (2019)

Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis
por: Narra, Hema P., et al.
Publicado: (2022)

Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP
por: Schumacher, Maria A., et al.
Publicado: (2022)

2′-Fluoro-c-di-GMP as an oral vaccine adjuvant
por: Li, Jia, et al.
Publicado: (2019)

DEMONSTRATION OF SURFACE ANTIGENS AND PINOCYTOSIS IN MAMMALIAN CELLS WITH FERRITIN-ANTIBODY CONJUGATES
por: Easton, John M., et al.
Publicado: (1962)

Genetic Engineering of Lactococcus lactis Co-producing Antigen and the Mucosal Adjuvant 3′ 5′- cyclic di Adenosine Monophosphate (c-di-AMP) as a Design Strategy to Develop a Mucosal Vaccine Prototype
por: Quintana, Ingrid, et al.
Publicado: (2018)

Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
por: Ruksakiet, Kasidid, et al.
Publicado: (2021)

Reversible pinocytosis in polymorphonuclear leukocytes
Publicado: (1983)

Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP—AMP to control predation in Bdellovibrio bacteriovorus
por: Rangarajan, Aathmaja Anandhi, et al.
Publicado: (2022)

Cyclic di-GMP-dependent Signaling Pathways in the Pathogenic Firmicute Listeria monocytogenes
por: Chen, Li-Hong, et al.
Publicado: (2014)

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective
por: Agostoni, Marco, et al.
Publicado: (2013)

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
por: Novak, Elizabeth A., et al.
Publicado: (2014)

Physiological and Microscopic Characterization of Cyclic-di-GMP-Mediated Autoaggregation in Erwinia amylovora
por: Kharadi, Roshni R., et al.
Publicado: (2019)

Hybrid histidine kinase activation by cyclic di-GMP–mediated domain liberation
por: Dubey, Badri N., et al.
Publicado: (2020)

Control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP
por: Enomoto, Gen, et al.
Publicado: (2023)

CRP-Cyclic AMP Regulates the Expression of Type 3 Fimbriae via Cyclic di-GMP in Klebsiella pneumoniae
por: Lin, Ching-Ting, et al.
Publicado: (2016)

CORRELATION BETWEEN PINOCYTOSIS AND HYDROOSMOSIS INDUCED BY NEUROHYPOPHYSEAL HORMONES AND MEDIATED BY ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE
por: Masur, Sandra K., et al.
Publicado: (1971)

Cannot write session to /tmp/vufind_sessions/sess_4jgfg4k1s26df750hrje6ed9hd