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Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
BACKGROUND: Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson’s disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a common genetic risk factor for...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428238/ https://www.ncbi.nlm.nih.gov/pubmed/25881142 http://dx.doi.org/10.1186/s13024-015-0010-2 |