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Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies

BACKGROUND: Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson’s disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a common genetic risk factor for...

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Detalles Bibliográficos
Autores principales:	Chiasserini, Davide, Paciotti, Silvia, Eusebi, Paolo, Persichetti, Emanuele, Tasegian, Anna, Kurzawa-Akanbi, Marzena, Chinnery, Patrick F, Morris, Christopher M, Calabresi, Paolo, Parnetti, Lucilla, Beccari, Tommaso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428238/ https://www.ncbi.nlm.nih.gov/pubmed/25881142 http://dx.doi.org/10.1186/s13024-015-0010-2

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