A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization

Mutations in the juxtamembrane and tyrosine kinase domains of the KIT receptor have been implicated in several cancers and are known to promote tumorigenesis. However, the pathophysiological manifestations of mutations in the extracellular domain remain unknown. In this study, we examined the impact...

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Detalles Bibliográficos
Autores principales: Amagai, Yosuke, Matsuda, Akira, Jung, Kyungsook, Oida, Kumiko, Jang, Hyosun, Ishizaka, Saori, Matsuda, Hiroshi, Tanaka, Akane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428273/
https://www.ncbi.nlm.nih.gov/pubmed/25965812
http://dx.doi.org/10.1038/srep09775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428273/
https://www.ncbi.nlm.nih.gov/pubmed/25965812
http://dx.doi.org/10.1038/srep09775

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