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Memory Impairment and Reduced Exploratory Behavior in Mice after Administration of Systemic Morphine
In the present study, the effects of morphine were examined on tests of spatial memory, object exploration, locomotion, and anxiety in male ICR mice. Administration of morphine (15 or 30 mg/kg, intraperitoneally (i.p.)) induced a significant decrease in Y-maze alternations compared to saline vehicle...
Autores principales: | Kitanaka, Junichi, Kitanaka, Nobue, Hall, F Scott, Fujii, Mei, Goto, Akiko, Kanda, Yusuke, Koizumi, Akira, Kuroiwa, Hirotoshi, Mibayashi, Satoko, Muranishi, Yumi, Otaki, Soichiro, Sumikawa, Minako, Tanaka, Koh-ichi, Nishiyama, Nobuyoshi, Uhl, George R, Takemura, Motohiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428380/ https://www.ncbi.nlm.nih.gov/pubmed/25987850 http://dx.doi.org/10.4137/JEN.S25057 |
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