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Trapping a salt-dependent unfolding intermediate of the marginally stable protein Yfh1

Yfh1, the yeast ortholog of frataxin, is a protein of limited thermodynamic stability which undergoes cold denaturation at temperatures above the water freezing point. We have previously demonstrated that its stability is strongly dependent on ionic strength and that monovalent or divalent cations a...

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Detalles Bibliográficos
Autores principales: Vilanova, Bartolomé, Sanfelice, Domenico, Martorell, Gabriel, Temussi, Piero A., Pastore, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428383/
https://www.ncbi.nlm.nih.gov/pubmed/25988154
http://dx.doi.org/10.3389/fmolb.2014.00013