Synthesis, Preferentially Hypoxic Apoptosis and Anti-Angiogenic Activity of 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide Bearing Alkyl Linkers with a 3-Amino-1,2,4-Benzotriazine-1-Oxide Moiety

3-(Aminoalkylamino)-1,2,4-benzotriazine-1,4-dioxide-extended derivatives were synthesized by the structural modification of 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) that incorporated homologue-alkyl linkers, without or with an extended 3-amino-1,2,4-benzotriazine-1-oxide moiety at...

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Detalles Bibliográficos
Autores principales: Lee, Chun-I, Huang, Chien-Ming, Huang, Wen-Hsin, Lee, An-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428392/
https://www.ncbi.nlm.nih.gov/pubmed/25312508
http://dx.doi.org/10.2174/1871520614666141014130554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428392/
https://www.ncbi.nlm.nih.gov/pubmed/25312508
http://dx.doi.org/10.2174/1871520614666141014130554

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