ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

Parkinson's disease and dementia with Lewy bodies are neurodegenerative disorders characterized by accumulation of α-synuclein (α-syn). Recently, single-chain fragment variables (scFVs) have been developed against individual conformational species of α-syn. Unlike more traditional monoclonal an...

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Detalles Bibliográficos
Autores principales: Spencer, Brian, Emadi, Sharareh, Desplats, Paula, Eleuteri, Simona, Michael, Sarah, Kosberg, Kori, Shen, Jay, Rockenstein, Edward, Patrick, Christina, Adame, Anthony, Gonzalez, Tania, Sierks, Michael, Masliah, Eliezer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428402/
https://www.ncbi.nlm.nih.gov/pubmed/25008355
http://dx.doi.org/10.1038/mt.2014.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428402/
https://www.ncbi.nlm.nih.gov/pubmed/25008355
http://dx.doi.org/10.1038/mt.2014.129

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