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Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS

Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.). During the past decades, it has been well documented that this phenolic compound has health benefits and a protective action has been found in preclinical studies...

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Autores principales: Vilaplana-Pérez, Cristina, Auñón, David, García-Flores, Libia A., Gil-Izquierdo, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428486/
https://www.ncbi.nlm.nih.gov/pubmed/25988120
http://dx.doi.org/10.3389/fnut.2014.00018
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author Vilaplana-Pérez, Cristina
Auñón, David
García-Flores, Libia A.
Gil-Izquierdo, Angel
author_facet Vilaplana-Pérez, Cristina
Auñón, David
García-Flores, Libia A.
Gil-Izquierdo, Angel
author_sort Vilaplana-Pérez, Cristina
collection PubMed
description Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.). During the past decades, it has been well documented that this phenolic compound has health benefits and a protective action has been found in preclinical studies against several diseases. Here, we review its bioavailability in human beings and several assays showing significant results related with cardiovascular diseases, cancer, and acquired immunodeficiency syndrome (AIDS). Mechanisms of action include potent anti-oxidant and anti-inflammatory effects, among others. The importance of hydroxytyrosol in protection of low-density lipoproteins and consequently its implication in the reduction of cardiovascular disease risk has been highlighted by the European Food Safety Authority, concluding that 5 mg of hydroxytyrosol and its derivatives should be consumed daily to reach this effect at physiological level. We discuss the potential uses of this compound in supplements, nutraceutic foods, or topical formulations in the disease risk reduction. Finally, we conclude that more studies are needed to sustain or reject many other health claims not yet fully documented and to validate these newly available hydroxytyrosol-based products, because it seems to be a good candidate to reduce the risk of diseases mentioned.
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spelling pubmed-44284862015-05-18 Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS Vilaplana-Pérez, Cristina Auñón, David García-Flores, Libia A. Gil-Izquierdo, Angel Front Nutr Nutrition Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.). During the past decades, it has been well documented that this phenolic compound has health benefits and a protective action has been found in preclinical studies against several diseases. Here, we review its bioavailability in human beings and several assays showing significant results related with cardiovascular diseases, cancer, and acquired immunodeficiency syndrome (AIDS). Mechanisms of action include potent anti-oxidant and anti-inflammatory effects, among others. The importance of hydroxytyrosol in protection of low-density lipoproteins and consequently its implication in the reduction of cardiovascular disease risk has been highlighted by the European Food Safety Authority, concluding that 5 mg of hydroxytyrosol and its derivatives should be consumed daily to reach this effect at physiological level. We discuss the potential uses of this compound in supplements, nutraceutic foods, or topical formulations in the disease risk reduction. Finally, we conclude that more studies are needed to sustain or reject many other health claims not yet fully documented and to validate these newly available hydroxytyrosol-based products, because it seems to be a good candidate to reduce the risk of diseases mentioned. Frontiers Media S.A. 2014-10-27 /pmc/articles/PMC4428486/ /pubmed/25988120 http://dx.doi.org/10.3389/fnut.2014.00018 Text en Copyright © 2014 Vilaplana-Pérez, Auñón, García-Flores and Gil-Izquierdo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Vilaplana-Pérez, Cristina
Auñón, David
García-Flores, Libia A.
Gil-Izquierdo, Angel
Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title_full Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title_fullStr Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title_full_unstemmed Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title_short Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
title_sort hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and aids
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428486/
https://www.ncbi.nlm.nih.gov/pubmed/25988120
http://dx.doi.org/10.3389/fnut.2014.00018
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