A Ribonucleoprotein Complex Protects the Interleukin-6 mRNA from Degradation by Distinct Herpesviral Endonucleases

During lytic Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, the viral endonuclease SOX promotes widespread degradation of cytoplasmic messenger RNA (mRNA). However, select mRNAs escape SOX-induced cleavage and remain robustly expressed. Prominent among these is interleukin-6 (IL-6), a gro...

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Detalles Bibliográficos
Autores principales: Muller, Mandy, Hutin, Stephanie, Marigold, Oliver, Li, Kathy H., Burlingame, Al, Glaunsinger, Britt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428876/
https://www.ncbi.nlm.nih.gov/pubmed/25965334
http://dx.doi.org/10.1371/journal.ppat.1004899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428876/
https://www.ncbi.nlm.nih.gov/pubmed/25965334
http://dx.doi.org/10.1371/journal.ppat.1004899

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