Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria

BACKGROUND: Haemoglobin variants, Sickle (HbS) and foetal (HbF) have been associated with malaria protection. This study explores epistatic interactions between HbS and HbF on malaria infection. METHODS: The study was conducted between March 2004 and December 2013 within the sickle cell disease (SCD...

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Detalles Bibliográficos
Autores principales: Mmbando, Bruno P., Mgaya, Josephine, Cox, Sharon E., Mtatiro, Siana N., Soka, Deogratias, Rwezaula, Stella, Meda, Elineema, Msaki, Evarist, Snow, Robert W., Jeffries, Neal, Geller, Nancy L., Makani, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428884/
https://www.ncbi.nlm.nih.gov/pubmed/25965586
http://dx.doi.org/10.1371/journal.pone.0125929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428884/
https://www.ncbi.nlm.nih.gov/pubmed/25965586
http://dx.doi.org/10.1371/journal.pone.0125929

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