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The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

OBJECTIVES: It is a matter of debate whether impaired insulin action originates from a defect at the neural level or impaired transport of the hormone into the brain. In this study, we aimed to investigate the effect of aging on insulin concentrations in the periphery and the central nervous system...

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Detalles Bibliográficos
Autores principales: Sartorius, Tina, Peter, Andreas, Heni, Martin, Maetzler, Walter, Fritsche, Andreas, Häring, Hans-Ulrich, Hennige, Anita M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429020/
https://www.ncbi.nlm.nih.gov/pubmed/25965336
http://dx.doi.org/10.1371/journal.pone.0126804