In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus

Metformin (Met) is a biguanide anti-hyperglycemic agent, which also exerts antiproliferative effects on cancer cells. This drug inhibits the complex I of the mitochondrial electron transport chain inducing a fall in the cell energy charge and leading 5'-AMP-activated protein kinase (AMPK) activ...

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Detalles Bibliográficos
Autores principales: Loos, Julia A., Cumino, Andrea C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429119/
https://www.ncbi.nlm.nih.gov/pubmed/25965910
http://dx.doi.org/10.1371/journal.pone.0126009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429119/
https://www.ncbi.nlm.nih.gov/pubmed/25965910
http://dx.doi.org/10.1371/journal.pone.0126009

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