Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes

Our investigation showed that hepatocytes isolated from cysteine dioxygenase knockout mice (Cdo1(−/−)) had lower levels of hypotaurine and taurine than Cdo1 (+/+) hepatocytes. Interestingly, hypotaurine accumulates in cultured wild-type hepatocytes. dl-propargylglycine (PPG, inhibitor of cystathioni...

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Detalles Bibliográficos
Autores principales: Jurkowska, Halina, Stipanuk, Martha H., Hirschberger, Lawrence L., Roman, Heather B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429143/
https://www.ncbi.nlm.nih.gov/pubmed/25772816
http://dx.doi.org/10.1007/s00726-015-1948-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429143/
https://www.ncbi.nlm.nih.gov/pubmed/25772816
http://dx.doi.org/10.1007/s00726-015-1948-7

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