Cargando…

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

BACKGROUND: Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor sign...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pignochino, Ymera, Dell’Aglio, Carmine, Inghilleri, Simona, Zorzetto, Michele, Basiricò, Marco, Capozzi, Federica, Canta, Marta, Piloni, Davide, Cemmi, Francesca, Sangiolo, Dario, Gammaitoni, Loretta, Soster, Marco, Marchiò, Serena, Pozzi, Ernesto, Morbini, Patrizia, Luisetti, Maurizio, Aglietta, Massimo, Grignani, Giovanni, Stella, Giulia M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429519/ https://www.ncbi.nlm.nih.gov/pubmed/25952930 http://dx.doi.org/10.1186/s12885-015-1363-1

Ejemplares similares

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models
por: Pignochino, Ymera, et al.
Publicado: (2017)

Activation of Oncogenic Pathways in Idiopathic Pulmonary Fibrosis
por: Stella, Giulia M., et al.
Publicado: (2014)

Cytokine Induced Killer cells are effective against sarcoma cancer stem cells spared by chemotherapy and target therapy.
por: Mesiano, Giulia, et al.
Publicado: (2018)

Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
por: Stella, Giulia M, et al.
Publicado: (2011)

Erratum to “Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study”
por: Inghilleri, S., et al.
Publicado: (2011)

Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
por: Sangiolo, Dario, et al.
Publicado: (2014)

Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study
por: Inghilleri, Simona, et al.
Publicado: (2011)

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
por: Pignochino, Ymera, et al.
Publicado: (2009)

Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST
por: Fiorino, Erika, et al.
Publicado: (2022)

Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights
por: Chiabotto, Giulia, et al.
Publicado: (2020)

PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas—A Preclinical and Translational Study
por: Pignochino, Ymera, et al.
Publicado: (2021)

Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy
por: Goracci, Martina, et al.
Publicado: (2020)

EphA2 Expression in Bone Sarcomas: Bioinformatic Analyses and Preclinical Characterization in Patient-Derived Models of Osteosarcoma, Ewing’s Sarcoma and Chondrosarcoma
por: Giordano, Giorgia, et al.
Publicado: (2021)

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models
por: Peraldo-Neia, Caterina, et al.
Publicado: (2014)

CD44v6 as innovative sarcoma target for CAR-redirected CIK cells
por: Leuci, V., et al.
Publicado: (2018)

Cytokine Profiling of End Stage Cancer Patients Treated with Immunotherapy
por: Merlano, Marco Carlo, et al.
Publicado: (2021)

Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti‐leukaemic potential and alloreactivity across major human leukocyte antigen barriers
por: Circosta, Paola, et al.
Publicado: (2022)

CAR-Based Strategies beyond T Lymphocytes: Integrative Opportunities for Cancer Adoptive Immunotherapy
por: Rotolo, Ramona, et al.
Publicado: (2019)

DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination
por: Merlini, Alessandra, et al.
Publicado: (2022)

Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study
por: Cova, Emanuela, et al.
Publicado: (2019)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma
por: Giraudo, Lidia, et al.
Publicado: (2023)

Cytokine Induced Killer cells effectively kill chemo-resistant melanoma cancer stem cells
por: Gammaitoni, Loretta, et al.
Publicado: (2015)

Recruitment, Infiltration, and Cytotoxicity of HLA-Independent Killer Lymphocytes in Three-Dimensional Melanoma Models
por: Iaia, Ilenia, et al.
Publicado: (2021)

La práctica del perito trabajador social : una propuesta metodológica de intervención social /
por: Dell'Aglio, Marta
Publicado: (2004)

New insights in transcriptional control of somatic embryogenesis: the role of AGAMOUS-like 18
por: Dell’Aglio, Elisa
Publicado: (2022)

Breaking the barrier: Mg hyperaccumulation in Brassica rapa endodermal mutants
por: Dell’Aglio, Elisa
Publicado: (2021)

A COG in the machine: how good Golgi makes good pollen
por: Dell’Aglio, Elisa
Publicado: (2021)

Exosome-Based Liquid Biopsy Approaches in Bone and Soft Tissue Sarcomas: Review of the Literature, Prospectives, and Hopes for Clinical Application
por: Agnoletto, Chiara, et al.
Publicado: (2023)

ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells
por: Dumontel, Bianca, et al.
Publicado: (2019)

Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient
por: Torchiaro, Erica, et al.
Publicado: (2023)

Unexpected responses to EGFR inhibition in NSCLC
por: Stella, Giulia M., et al.
Publicado: (2015)

Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1(+) Chemoresistant Lung Cancer Cells
por: Rotolo, Ramona, et al.
Publicado: (2023)

Multicomponent positive psychology intervention for health promotion of Brazilian retirees: a quasi-experimental study
por: Durgante, Helen, et al.
Publicado: (2019)

Fluoropyrimidine-induced cardiotoxicity in colorectal cancer patients: a prospective observational trial (CHECKPOINT)
por: Lombardi, Pasquale, et al.
Publicado: (2022)

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer
por: Peraldo-Neia, Caterina, et al.
Publicado: (2011)

Establishment and characterization of a human intrahepatic cholangiocarcinoma cell line derived from an Italian patient
por: Cavalloni, Giuliana, et al.
Publicado: (2015)

5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin
por: Bosio, Matteo, et al.
Publicado: (2018)

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity
por: Leuci, V., et al.
Publicado: (2016)

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas
por: Pignochino, Ymera, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_0vc2btnush320um8dl1am55grg