Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction

Human dose-prediction is fundamental for ranking lead-optimization compounds in drug discovery and to inform design of early clinical trials. This tutorial describes how uncertainty in such predictions can be quantified and efficiently communicated to facilitate decision-making. Using three drug-dis...

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Detalles Bibliográficos
Autores principales: Sundqvist, M, Lundahl, A, Någård, MB, Bredberg, U, Gennemark, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429578/
https://www.ncbi.nlm.nih.gov/pubmed/26225248
http://dx.doi.org/10.1002/psp4.32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429578/
https://www.ncbi.nlm.nih.gov/pubmed/26225248
http://dx.doi.org/10.1002/psp4.32

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