The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization

BACKGROUND: The nuclear receptors PPAR-γ and LXRs regulate macrophage lipid metabolism and macrophage mediated inflammation. We examined the influence of these molecules on macrophage alternative activation, with particular focus on differentiation of “M2c” anti-inflammatory cells. METHODS: We cultu...

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Detalles Bibliográficos
Autores principales: Zizzo, Gaetano, Cohen, Philip L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429687/
https://www.ncbi.nlm.nih.gov/pubmed/25972766
http://dx.doi.org/10.1186/s12950-015-0081-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429687/
https://www.ncbi.nlm.nih.gov/pubmed/25972766
http://dx.doi.org/10.1186/s12950-015-0081-4

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