LTB4 causes macrophage–mediated inflammation and directly induces insulin resistance in obesity

Chronic inflammation is a key component of obesity–induced insulin resistance and plays a central role in metabolic disease. In this study, we found that the major insulin target tissues, liver, muscle and adipose tissue exhibit increased levels of the chemotactic eicosanoid LTB4 in obese high fat d...

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Detalles Bibliográficos
Autores principales: Li, Pingping, Oh, Da Young, Bandyopadhyay, Gautam, Lagakos, William S., Talukdar, Saswata, Osborn, Olivia, Johnson, Andrew, Chung, Heekyung, Maris, Michael, Ofrecio, Jachelle M., Taguchi, Sayaka, Lu, Min, Olefsky, Jerrold M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429798/
https://www.ncbi.nlm.nih.gov/pubmed/25706874
http://dx.doi.org/10.1038/nm.3800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429798/
https://www.ncbi.nlm.nih.gov/pubmed/25706874
http://dx.doi.org/10.1038/nm.3800

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