CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Dendritic cells (DCs) are critical for immune homeostasis. To target DCs, we generated a mouse line with Flip deficiency in cells that express cre under the CD11c promoter (CD11c-Flip-KO). CD11c-Flip-KO mice spontaneously develop erosive, inflammatory arthritis, resembling rheumatoid arthritis, whic...

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Detalles Bibliográficos
Autores principales: Huang, Qi-Quan, Perlman, Harris, Birkett, Robert, Doyle, Renee, Fang, Deyu, Haines, G. Kenneth, Robinson, William, Datta, Syamal, Huang, Zan, Li, Quan-Zhen, Phee, Hyewon, Pope, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429912/
https://www.ncbi.nlm.nih.gov/pubmed/25963626
http://dx.doi.org/10.1038/ncomms8086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429912/
https://www.ncbi.nlm.nih.gov/pubmed/25963626
http://dx.doi.org/10.1038/ncomms8086

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