Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet

We showed previously that UBXD8 plays a key role in proteasomal degradation of lipidated ApoB in hepatocarcinoma cell lines. In the present study, we aimed to investigate the functions of UBXD8 in liver in vivo. For this purpose, hepatocyte-specific UBXD8 knockout (UBXD8-LKO) mice were generated. Th...

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Detalles Bibliográficos
Autores principales: Imai, Norihiro, Suzuki, Michitaka, Hayashi, Kazuhiko, Ishigami, Masatoshi, Hirooka, Yoshiki, Abe, Takaya, Shioi, Go, Goto, Hidemi, Fujimoto, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430229/
https://www.ncbi.nlm.nih.gov/pubmed/25970332
http://dx.doi.org/10.1371/journal.pone.0127114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430229/
https://www.ncbi.nlm.nih.gov/pubmed/25970332
http://dx.doi.org/10.1371/journal.pone.0127114

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