Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity

Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown. In this study, we addressed this issue in human cancer cells in respo...

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Detalles Bibliográficos
Autores principales: Zha, Qing-Bing, Zhang, Xiao-Yu, Lin, Qiu-Ru, Xu, Li-Hui, Zhao, Gao-Xiang, Pan, Hao, Zhou, Dan, Ouyang, Dong-Yun, Liu, Ze-Huan, He, Xian-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430304/
https://www.ncbi.nlm.nih.gov/pubmed/25970614
http://dx.doi.org/10.1371/journal.pone.0124355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430304/
https://www.ncbi.nlm.nih.gov/pubmed/25970614
http://dx.doi.org/10.1371/journal.pone.0124355

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